Research

Massachusetts Consortium on Pathogen Readiness (MassCPR)

Request for Proposals (RFP) Award Recipients

 

July 2020

 

63 awards (including 17 key research resources), over $17.5 million in total funding

 

Key research resources are infrastructure, platforms, tools, and skilled personnel that enable multiple investigators in the MassCPR to perform multidisciplinary research projects; these awards are denoted by an asterisk*
List is alphabetical by PI last name
 
Coronavirus cross-reactive monoclonal antibodies from COVID-19 convalescent individuals
Jonathan Abraham (Harvard Medical School)
 
Systems based Fc-engineering to accelerate therapeutic monoclonal antibody design to COVID-19
Galit Alter (Ragon Institute of MGH, MIT, and Harvard)
 
Rapidly conducting clinical trials of novel therapies for SARS-CoV-2 using adaptive design strategies*
Lindsey Baden (Brigham and Women’s Hospital)
 
Rapidly deployable ventilator splitters to accommodate COVID-19 patient surges
Rebecca Baron (Brigham and Women’s Hospital)
 
Protective immunity to SARS-CoV-2 by natural infection and vaccination
Dan Barouch (Beth Israel Deaconess Medical Center)
 
Support for clinical specimen procurement at Beth Israel Deaconess Medical Center*
Dan Barouch (Beth Israel Deaconess Medical Center)
 
Novel nanocarbon materials for life-development of distributable textiles that filtrate/neutralize dangerous viruses/bacteria to protect medical professionals and civilians from virus pandemic disease, such as COVID-19
Angela Belcher (Massachusetts Institute of Technology)
 
Decoding the T cell response to SARS-CoV-2
Christophe Benoist (Harvard Medical School)
 
COVID Structural Biology Funding*
Stephen Blacklow (Harvard Medical School)
 
COVID-19 surveillance and forecasting platform
John Brownstein (Boston Children’s Hospital)
 
Identification of transcriptional pathways and cell states associated with COVID-19 severity in minority and underserved populations
Joshua Campbell (Boston University)
 
COronavirus Pandemic Epidemiology (COPE)
Andrew Chan (Massachusetts General Hospital)
 
Production of the full-length soluble coronavirus spike (S) protein and ACE2*
Bing Chen (Boston Children’s Hospital)
 
Enhancing mRNA-based coronavirus vaccines with lymph node-targeted delivery and neutralizing antibody-inducing adjuvant
Jianzhu Chen (Massachusetts Institute of Technology)
 
Staff scientists/veterinary technicians at the NEIDL BSL3/4*
Ronald Corley (Boston University)
 
HTS for identification and evaluation of efficacy for therapeutics against SARS-CoV-2 infection*
Robert Davey (Boston University)
 
Evaluating the association between symptoms and COVID-19 test results among health care workers (COVID-HCW)
Michael Dougan (Massachusetts General Hospital)
 
Analysis of COVID-19 immune responses
Stephen Elledge (Brigham and Women’s Hospital)
 
Wastewater-based epidemiology to rapidly diagnose and map the COVID-19 pandemic
Timothy Erickson (Brigham and Women’s Hospital)
 
Identifying and targeting host cells and genes crucial in SARS-CoV-2 pathogenesis
Robert Finberg (University of Massachusetts Medical School)
 
A simple and direct antigen rapid test for SARS-CoV-2 infections: ready for scale-up
Lee Gehrke (Massachusetts Institute of Technology)
 
Molecular and structural analysis of B-cell repertoire in children and adults following infection with SARS-CoV-2
Stephen Harrison (Boston Children’s Hospital and Harvard Medical School)
 
Senior advisor for clinical partnerships*
Howard Heller (Harvard Medical School)
 
Characterization of SARS-CoV-2 aerosols and surface contamination produced during respiratory support therapy of COVID-19 patients
Nicholas Hill (Tufts Medical Center)
 
Contribution to Broad Institute for CLIA COVID-19 testing setup*
Deborah Hung (Broad Institute of MIT and Harvard)
 
Support for clinical specimen procurement at Boston Medical Center*
Karen Jacobson (Boston Medical Center)
 
Support for clinical specimen procurement at Tufts Medical Center*
Michael Jordan (Tufts Medical Center)
 
Open label, randomized controlled Phase 2 study of the use of favipiravir compared to standard of care in hospitalized subjects with COVID-19
Boris Juelg (Massachusetts General Hospital)
 
Herpesviral recombinant vectors for vaccine vectors and study of coronaviral pathogenesis
David Knipe (Harvard Medical School)
 
Clinical impact and outcomes of COVID-19 in immunocompromised hosts
Sophia Koo (Brigham and Women’s Hospital)
 
Human iPSC-derived lung organoids for modeling COVID-19 infection
Darrell Kotton (Boston University)
 
Rapid discovery and development of an adjuvanted SARS-CoV-2 vaccine optimized for immunogenicity in the elderly
Ofer Levy (Boston Children’s Hospital)
 
Rapid functional assessment of SARS-CoV-2 variants within the context of the pandemic
Jeremy Luban (University of Massachusetts Medical School)
 
Differential humoral immune response in children and adults with COVID-19
Richard Malley (Boston Children’s Hospital)
 
Therapeutic human antibodies against pathogenic coronaviruses that emerge from Southeast Asia including SARS-CoV2
Wayne Marasco (Dana Farber Cancer Institute)
 
Peptide:MHCII tetramer reagents for COVID-19 T cell studies
James Moon (Massachusetts General Hospital)
 
Age-associated development of antibody-mediated cytotoxic immunity to SARS-CoV-2, the virus that causes COVID-19 Disease
Ann Moormann (University of Massachusetts Medical School)
 
BWH-Critical Care Cardiology Trials Network (CCCTN) multidisciplinary collaborative study on the cardiovascular complications of COVID-19
David Morrow (Brigham and Women’s Hospital)
 
SARS-CoV-2 infection platforms and development of virological tools to combat the COVID-19 pandemic*
Elke Mühlberger (Boston University)
 
Large scale, cost-efficient screening and detection of SARS-CoV-2 (COVID-19) in the underserved population
George Murphy (Boston University)
 
BCG vaccination in healthcare workers for COVID-19
Megan Murray (Harvard Medical School)
 
Infrastructure to design and synthesize novel, broad spectrum inhibitors of SARS-CoV-2 targets, starting with the 3CLpro and PLpro coronavirus proteases*
Mark Namchuk (Harvard Medical School)
 
Small molecule therapeutics against SARS-CoV-2
Mark Namchuk (Harvard Medical School)
 
Endothelial-targeted therapy for COVID-19 acute respiratory distress syndrome
Samir Parikh (Beth Israel Deaconess Medical Center)
 
The mental health consequences of COVID-19 in four high-risk groups
Vikram Patel (Harvard Medical School)
 
Pulmozyme to improve COVID-19 ARDS outcomes
Benjamin Raby (Boston Children’s Hospital)
 
Modeling COVID-19 infection with in vitro models of human lung
Jayaraj Rajagopal (Massachusetts General Hospital)
 
SARS-CoV-2 genomic epidemiology: leveraging insights from ancient DNA
David Reich (Harvard Medical School)
 
Production of the receptor-binding domains (RBDs) from human coronaviruses (CoVs)*
Aaron Schmidt (Ragon Institute of MGH, MIT, and Harvard)
 
Optimization of ACE2 models*
Arlene Sharpe (Harvard Medical School)
 
A rapid, inexpensive, and versatile SARS-CoV-2 molecular diagnostic test
Michael Springer (Harvard Medical School)
 
Update to the HGHI COVID-19 US Hospital Capacity Model: ICU surge, post-acute care beds, and survey of mechanical ventilator supply
Thomas Tsai (Harvard T.H. Chan School of Public Health) and Ashish Jha (Harvard T.H. Chan School of Public Health)
 
AAVCOVID: a rapidly deployable SARS-nCoV-2 genetic vaccine for vulnerable populations through academia-industry partnership
Luk Vandenberghe (Massachusetts Eye and Ear)
 
Use of bisphosphonates in the therapy and prophylaxis of COVID-19 infection
Ulrich von Andrian (Harvard Medical School)
 
A highly networked, exosome-based SARS-CoV-2 vaccine
Bruce Walker (Ragon Institute of MGH, MIT, and Harvard)
 
Staff scientist at Ragon BSL3*
Bruce Walker (Ragon Institute of MGH, MIT, and Harvard)
 
Contribution to BWH Diagnostics Accelerator*
David Walt (Brigham and Women’s Hospital)
 
Detecting the host immune response to SARS-CoV-2 in patient blood using ultra-sensitive assays
David Walt (Brigham and Women’s Hospital)
 
The human antibody response to SARS-CoV-2
Duane Wesemann (Brigham and Women’s Hospital)
 
Rapid point-of-care COVID-19 diagnostics using DNA nanoswitches
Wesley Wong (Boston Children’s Hospital)
 
COVID-19 sample procurement, processing, storage, and sharing/distribution*
Xu Yu (Ragon Institue of MGH, MIT, and Harvard), Jonathan Li (Brigham and Women’s Hospital), and Lindsey Baden (Brigham and Women’s Hospital)
 
Development of a point-of-care diagnostic for COVID-19
Feng Zhang (Massachusetts Institute of Technology)
 
Quantify the role of social distancing in shaping the COVID-19 curve: incorporating adaptive behavior and preference shifts in epidemiological models using novel Big Data in 344 Chinese cities
Siqi Zheng (Massachusetts Institute of Technology)