Clinical Management and Outcomes Research

Working Group Leads

Lindsey Baden Lindsey R. Baden, M.D.
Director of Center for Clinical Investigation, BWH
Director of Infectious Diseases, DFCI
Associate Professor, HMS
Ingrid Bassett
Ingrid V. Bassett, M.D., M.P.H.
Associate Professor of Medicine, MGH
Rajesh Gandhi

Rajesh Gandhi, M.D.
Professor of Medicine, HMS
Director, HIV Clinical Services and Education, MGH

Karen Jacobson
Karen R. Jacobson, M.D., M.P.H.
Associate Professor of Medicine, BU School of Medicine
Director, Boston Medical Center Tuberculosis clinic


Clinical Management and Outcomes Research Working Group

The Clinical Management and Outcomes Research Working Group is focused on improving medical outcomes through understanding the behavior and physiologic effects of COVID-19 and identifying and optimizing effective treatments and supportive care. Working with patient-derived, clinical data, the working group strives to understand and optimize treatments ranging from monoclonal antibodies and antivirals, which focus on curbing viral replication during the early stages of infection to the use of anti-inflammatory, immune-modulating and anticlotting treatments in the later stages of infection, as well as supportive care such as supplemental oxygen, anticlotting and ventilation to manage symptoms or severe disease and critical illness. While clinical management has improved dramatically over the past year, the group remains focused on optimizing treatment, better risk profiling of patients prone to developing severe disease to inform individualized treatment, and understanding how a variety of factors including age, comorbidities and preexisting conditions, patients’ immune status and various socio-economic determinants of health may affect COVID-19 outcomes.

The working group has contributed to the development of COVID-19 treatment guidelines for the Infectious Disease Society of America as well as the National Institutes of Health, published studies identifying the increased COVID-19 hospitalization rates of Hispanics in the Boston area, published case studies highlighting potential concerns of SARS-CoV-2 infection in specific patient populations, and continuously brought together experts to discuss and contextualize rapidly changing recommendations and data throughout the pandemic response.