Working Group Leads
Lindsey R. Baden, M.D. Director of Center for Clinical Investigation, BWH Director of Infectious Diseases, DFCI Associate Professor, HMS |
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Ingrid V. Bassett, M.D., M.P.H.
Associate Professor of Medicine, MGH
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Rajesh Gandhi, M.D. |
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Karen R. Jacobson, M.D., M.P.H.
Associate Professor of Medicine, BU School of Medicine
Director, Boston Medical Center Tuberculosis clinic
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Clinical Management and Outcomes Research Working Group
The Clinical Management and Outcomes Research Working Group is focused on improving medical outcomes through understanding the behavior and physiologic effects of COVID-19 and identifying and optimizing effective treatments and supportive care. Working with patient-derived, clinical data, the working group strives to understand and optimize treatments ranging from monoclonal antibodies and antivirals, which focus on curbing viral replication during the early stages of infection to the use of anti-inflammatory, immune-modulating and anticlotting treatments in the later stages of infection, as well as supportive care such as supplemental oxygen, anticlotting and ventilation to manage symptoms or severe disease and critical illness. While clinical management has improved dramatically over the past year, the group remains focused on optimizing treatment, better risk profiling of patients prone to developing severe disease to inform individualized treatment, and understanding how a variety of factors including age, comorbidities and preexisting conditions, patients’ immune status and various socio-economic determinants of health may affect COVID-19 outcomes.